Table 2. Genotype distribution and allele frequency of IL-12 polymorphisms.
First author | Genotype (N) | Allele frequency (N) | MAF | HWE | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Case | Control | Case | Control | |||||||||||
Total | AA | AB | BB | Total | AA | AB | BB | A | B | A | B | |||
rs568408 | ||||||||||||||
Tan 2015[14] | 395 | 313 | 76 | 6 | 686 | 511 | 161 | 14 | 702 | 80 | 1183 | 189 | 0.102 | 0.750 |
Sun 2015[20] | 257 | 172 | 83 | 2 | 236 | 181 | 55 | 0 | 427 | 89 | 417 | 55 | 0.172 | 0.040 |
Wang2013[37] | 106 | 66 | 37 | 3 | 210 | 156 | 47 | 7 | 169 | 61 | 359 | 61 | 0.265 | 0.150 |
Tao 2012[40] | 430 | 276 | 142 | 12 | 432 | 304 | 112 | 16 | 694 | 184 | 720 | 144 | 0.210 | 0.170 |
Roszak 2012[25] | 405 | 253 | 128 | 24 | 450 | 306 | 125 | 19 | 634 | 140 | 737 | 163 | 0.181 | 0.180 |
Liu 2011[16] | 802 | 504 | 277 | 21 | 861 | 631 | 220 | 10 | 1285 | 289 | 1482 | 240 | 0.184 | 0.060 |
Chen 2009[46] | 404 | 253 | 145 | 6 | 404 | 285 | 112 | 7 | 651 | 221 | 682 | 126 | 0.253 | 0.290 |
Hou 2007[23] | 257 | 211 | 8 | 38 | 428 | 306 | 112 | 10 | 430 | 8 | 724 | 132 | 0.018 | 0.950 |
Lee 2007[49] | 118 | 101 | 17 | 0 | 113 | 81 | 31 | 1 | 219 | 81 | 193 | 33 | 0.270 | 0.290 |
Wang 2006[50] | 941 | 671 | 238 | 32 | 1130 | 839 | 270 | 21 | 1580 | 238 | 1948 | 312 | 0.131 | 0.890 |
rs2243115 | ||||||||||||||
Tan 2015[14] | 395 | 326 | 63 | 6 | 685 | 549 | 128 | 8 | 715 | 75 | 1226 | 144 | 0.095 | 0.861 |
Sun 2015[20] | 257 | 225 | 31 | 1 | 236 | 212 | 24 | 0 | 481 | 33 | 448 | 24 | 0.064 | 0.411 |
Yin 2015[22] | 235 | 197 | 36 | 2 | 466 | 387 | 75 | 4 | 430 | 40 | 849 | 83 | 0.085 | 0.862 |
Wang2013[37] | 106 | 89 | 16 | 1 | 210 | 175 | 31 | 4 | 194 | 18 | 381 | 39 | 0.085 | 0.073 |
Sun 2013[38] | 368 | 311 | 56 | 1 | 370 | 308 | 58 | 4 | 678 | 58 | 674 | 66 | 0.079 | 0.499 |
Sima 2012[41] | 170 | 140 | 25 | 5 | 222 | 198 | 24 | 0 | 305 | 35 | 420 | 24 | 0.103 | 0.395 |
Liu 2011[16] | 861 | 735 | 125 | 1 | 874 | 732 | 137 | 5 | 1595 | 127 | 1601 | 147 | 0.074 | 0.604 |
Ter-Minassian 2011[45] | 248 | 115 | 113 | 20 | 317 | 180 | 114 | 23 | 343 | 153 | 474 | 160 | 0.308 | 0.403 |
Chen 2009[46] | 404 | 342 | 60 | 2 | 404 | 337 | 64 | 3 | 744 | 64 | 738 | 70 | 0.079 | 0.984 |
rs3212227 | ||||||||||||||
Tan 2015[14] | 395 | 104 | 201 | 90 | 686 | 200 | 347 | 139 | 409 | 381 | 747 | 625 | 0.482 | 0.605 |
Sun 2015[20] | 257 | 69 | 140 | 48 | 236 | 71 | 124 | 41 | 278 | 236 | 266 | 206 | 0.459 | 0.295 |
Yin 2015[22] | 234 | 60 | 132 | 42 | 466 | 152 | 221 | 93 | 252 | 216 | 525 | 407 | 0.462 | 0.436 |
Jafarzadeh 2015[35] | 100 | 58 | 32 | 10 | 100 | 59 | 33 | 8 | 148 | 52 | 151 | 49 | 0.260 | 0.280 |
Winchester 2015[36] | 866 | 535 | 274 | 57 | 830 | 568 | 227 | 35 | 1344 | 388 | 1363 | 297 | 0.224 | 0.046 |
Saxena 2014[15] | 59 | 19 | 31 | 9 | 148 | 63 | 71 | 14 | 69 | 49 | 197 | 99 | 0.415 | 0.345 |
Wang 2013[37] | 106 | 27 | 50 | 29 | 210 | 78 | 101 | 31 | 104 | 108 | 257 | 163 | 0.509 | 0.585 |
Sun 2013[38] | 368 | 116 | 176 | 76 | 370 | 112 | 179 | 79 | 408 | 328 | 403 | 337 | 0.446 | 0.635 |
Jaiswal 2013[39] | 200 | 87 | 94 | 19 | 200 | 111 | 74 | 15 | 268 | 132 | 296 | 104 | 0.330 | 0.590 |
Tao 2012[40] | 426 | 109 | 216 | 101 | 432 | 148 | 213 | 71 | 434 | 418 | 509 | 355 | 0.491 | 0.701 |
Sima 2012[41] | 170 | 66 | 86 | 18 | 222 | 71 | 116 | 35 | 218 | 122 | 258 | 186 | 0.359 | 0.275 |
Kaarvatn 2012[42] | 191 | 126 | 59 | 6 | 194 | 104 | 73 | 17 | 311 | 71 | 281 | 107 | 0.186 | 0.419 |
Carvalho 2012[26] | 162 | 100 | 49 | 13 | 76 | 31 | 37 | 8 | 249 | 75 | 99 | 53 | 0.231 | 0.531 |
Roszak 2012[25] | 405 | 212 | 174 | 19 | 450 | 289 | 151 | 10 | 598 | 212 | 729 | 171 | 0.262 | 0.056 |
Hu 2012[43] | 92 | 16 | 42 | 34 | 38 | 13 | 16 | 9 | 74 | 110 | 42 | 34 | 0.598 | 0.360 |
Huang 2012[21] | 410 | 93 | 219 | 98 | 450 | 124 | 230 | 96 | 405 | 415 | 478 | 422 | 0.506 | 0.578 |
Liu 2011[16] | 831 | 249 | 422 | 160 | 844 | 272 | 414 | 158 | 920 | 742 | 958 | 730 | 0.446 | 0.983 |
Chaaben 2011[44] | 247 | 74 | 124 | 49 | 284 | 135 | 118 | 31 | 272 | 222 | 388 | 180 | 0.449 | 0.497 |
Yang2011[19] | 608 | 156 | 309 | 143 | 612 | 195 | 302 | 115 | 621 | 595 | 692 | 532 | 0.489 | 0.919 |
Wu 2009[24] | 1035 | 347 | 508 | 180 | 1073 | 333 | 554 | 186 | 1202 | 868 | 1220 | 926 | 0.419 | 0.086 |
Chen 2009[46] | 404 | 127 | 199 | 78 | 404 | 150 | 185 | 69 | 453 | 355 | 485 | 323 | 0.439 | 0.357 |
Miteva 2009[13] | 85 | 50 | 31 | 4 | 134 | 80 | 45 | 9 | 131 | 39 | 205 | 63 | 0.229 | 0.443 |
Wei 2009[47] | 302 | 58 | 165 | 79 | 310 | 98 | 152 | 60 | 281 | 323 | 348 | 272 | 0.535 | 0.938 |
Zhao 2009[48] | 210 | 38 | 115 | 57 | 220 | 70 | 106 | 44 | 191 | 229 | 246 | 194 | 0.545 | 0.736 |
Ognjanovic 2009[17] | 117 | 57 | / | / | 223 | 128 | / | / | / | / | / | / | / | / |
Tamandani 2009[28] | 200 | 63 | 134 | 3 | 200 | 88 | 104 | 8 | 260 | 140 | 280 | 120 | 0.350 | 0.001 |
Han 2008[27] | 150 | 32 | 87 | 31 | 179 | 52 | 88 | 39 | 151 | 149 | 192 | 166 | 0.497 | 0.877 |
Wang 2006[50] | 926 | 565 | 310 | 51 | 1110 | 641 | 397 | 72 | 1440 | 412 | 1679 | 541 | 0.222 | 0.322 |
Nieters 2005[18] | 249 | 56 | / | / | 250 | 72 | / | / | / | / | / | / | / | / |
Howell2003[51] | 145 | 95 | 42 | 8 | 229 | 139 | 77 | 13 | 232 | 58 | 355 | 103 | 0.200 | 0.591 |
A: the major allele, B: the minor allele, MAF: minor allele frequencies; HWE: Hardy–Weinberg equilibrium.