Table 2. IC₅₀ of WCN-21, WND and WNP in different cell lines with different treatment time.

Cell lines		Topotecan	WCN-21	WND	WNP
Hep3B	24 h	0.4616 ± 0.02	0.27 ± 0.010	0.1674 ± 0.0032	0.09328 ± 0.0013
	48 h	0.1121 ± 0.0024	0.01838 ± 0.0028	0.007459 ± 0.001	0.003129 ± 0.0017
HepG2	24 h	1.594 ± 0.0206	0.5014 ± 0.0036	0.4035 ± 0.037	0.1375 ± 0.0062
	48 h	0.2847 ± 0.009	0.1836 ± 0.049	0.1007 ± 0.0038	0.05663 ± 0.058
Huh 7	24 h	0.5 ± 0.069	0.4017 ± 0.009	0.1719 ± 0.0032	0.07261 ± 0.0002
	48 h	0.1167 ± 0.048	0.07221 ± 0.012	0.05807 ± 0.0201	0.02625 ± 0.0405
L02	24 h	> 0.5	> 0.5	> 0.5	> 0.5
	48 h	> 0.5	> 0.5	> 0.5	0.490 ± 0.093

Data are expressed as mean ± SD of three independent samples.