Table 1. IC50 values for vosaroxin in glioma cell lines.
| Cell Line | IC50 ± SD (nM) | MGMT Status | P53 status | PTEN status |
|---|---|---|---|---|
| LN229 | 12.8 ± 2.3 | Methylated | Deficient | Mutated |
| U251 | 18.6 ± 2.4 | Methylated | Unfunctional | Mutated |
| SNB19 | 35.5 ± 7.0 | Methylated | Unfunctional | Mutated |
| SF268 | 50.3 ± 12.0 | Methylated | Unfunctional | PTEN-harboring |
| T98G | 64.5 ± 11.0 | Unmethylated | Unfunctional | PTEN-harboring |
| U138 | 65.8 ± 14.6 | Unmethylated | Deficient | PTEN-harboring |
| U373 | 78.4 ± 9.7 | Methylated | Unfunctional | Mutated |
| U118 | 88.5 ± 16.7 | Unmethylated | Deficient | Mutated |
| LN18 | 90.0 ± 12.5 | Unmethylated | Active (WT) | PTEN-harboring |
| A172 | 125.4 ± 89.4 | Methylated | Active (WT) | Mutated |
| U87MG | 140.9 ± 84.7 | Methylated | Active (WT) | PTEN-deficient |
| SW1783 | 260.5 ± 9.8 | Unmethylated | Unfunctional | Mutated |
| D54 | 190.0 ± 25.4 | Unmethylated | Active (WT) | Wild type |
| BT12M | 44.3 ± 5.5 | Unmethylated | Active (WT) | Wild type |
| CSCs-5 | 85.4 ± 7.8 | Methylated | Active (WT) | PTEN-deficient |
| CSCs-7 | 125.0 ± 15.4 | Unmethylated | Unfunctional | Wild type |
IC50: 50% inhibitory concentration; MGMT: O6-methylguanine methyltransferase; PTEN: phosphatase and tensin homolog (gene); SD: standard deviation; WT: wild type.