Table 5. Hazard ratios for disease-free survival and overall survival in orthotopic U251 models.

Treatments Compared	Disease-free Survival		Overall Survival
	HR (95% CI)	P Value	HR (95% CI)	P Value
TMZ vs VSR	2.0 (0.9–5.5)	0.06 (NS)	3.0 (1.0–8.8)	0.0446
RT vs VSR + RT	3.5 (1.2–9.9)	0.0007	9.9 (2.9–34.1)	< 0.0001
VSR vs VSR + RT	2.4 (1.1–8.8)	0.0244	4.5 (2.2–22.5)	0.0001
VSR vs TMZ + RT	1.2 (0.4–3.2)	0.66 (NS)	1.5 (0.5–3.0)	0.78 (NS)
VSR + RT vs TMZ + RT	2.5 (1.0–6.2)	0.0088	3.7 (1.2–11.0)	0.0198

CI: confidence interval; HR: hazard ratio; NS: not significant; RT: radiotherapy; TMZ: temozolomide; VSR: vosaroxin.