Skip to main content
. 2017 Mar 16;8(18):29963–29975. doi: 10.18632/oncotarget.16265

Figure 2. Comparative efficiency of the repair of DNA DSBs in HPV-negative and HPV-positive OPSCC cells.

Figure 2

(A) Cells were irradiated (4 Gy) and DNA DSBs measured at various time points post-IR by the neutral single cell gel electrophoresis (comet) assay. Shown is the % tail DNA with standard deviations from at least three independent experiments normalised to the levels seen immediately post-IR (0 min) which was set to 100 %. *p < 0.05, **p < 0.01, ***p < 0.005 as analysed by a one sample t-test of normalised % tail DNA values in the respective cells relative to the UMSCC6 cells at each particular time point. (B) Representative images of OPSCC cells visualised by the neutral comet assay, demonstrating defective repair of DNA DSBs in HPV-positive versus HPV-negative OPSCC cells.