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. 2017 Mar 16;8(18):30100–30111. doi: 10.18632/oncotarget.16279

Figure 6. MiR-21 mediates TNF-induced proliferation and migration in vascular smooth muscle cells and fibroblasts.

Figure 6

(A) Effects of miR-21 antagomir (miR-21i) on serum-driven cell proliferation in the absence and presence of TNF-a (T). (B) Effects of miR-21i on cell migration activity in the absence and presence of TNF-a. (C) Serum-driven cell proliferation in untreated (Con), scrambled control (scram)-treated and miR-21 mimic-treated cells. (D) The migration activity of untreated (Con), scrambled control (scram)-treated and miR-21 mimic-treated cells. (E) Representative images showing the involvement of miR-21 in mediating TNF-stimulated migration in smooth muscle cells and fibroblasts. Cells were stained with eosin. Data are mean ± SD. *P < 0.05 versus Con, #P < 0.05 versus Con+T, one-way ANOVA, n = 4.