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. 2017 Mar 31;8(18):30438–30454. doi: 10.18632/oncotarget.16737

Figure 8. A77 1726 induces p62 expression.

Figure 8

(A & B) Dose- and time-dependent induction of p62 by A77 1726.A375 cells were treated with the indicated concentration of A77 1726 or rapamycin (20 nM) (A) for 16 hr or treated with A77 1726 (200 μM) for the indicated time (B). Cell lysates were prepared and analyzed for p62 and actin expression. (C-E) A375 cells were treated with A77 1726 (200 μM) or leflunomide in the absence or presence of uridine (C), MAP kinase pathway inhibitors (D), or the PI-3 kinase inhibitors (E) for 16 hr. Cells were harvested and analyzed for p62 and actin levels by Western blot.