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. Author manuscript; available in PMC: 2017 May 25.
Published in final edited form as: Science. 2015 Jul 23;349(6252):1115–1120. doi: 10.1126/science.aac7049

Fig. 2. Absence of editing transcriptionally phenocopies loss of ADAR1.

Fig. 2

(A) MA plot comparing gene expression in WT and E861A E12.5 FL. Red dots, differentially expressed genes; blue dots, differentially expressed ISGs. (B) QuSAGE analysis of the top 100 differential pathway signatures ranked by fold enrichment and P value. (C) Heat map of the 50 most differentially expressed genes. Black dots indicate known ISGs. (D) qRT-PCR of ISGs in E861A compared with controls in FL and MEFs. Results are mean ± SEM (n = 3). *P < 0.05, **P < 0.005, and ***P < 0.0005 compared with Adar1+/+. (E) IU-dsRNA response gene set in E861A compared with WT samples (left) and Adar1−/− HSCs compared with controls (right).