Table 4. Diagnostic performance of biomarkers for diagnosis of JD.

Biomarker	AUC			P value			Cut-off (fold change)			Sensitivity (%)			Specificity (%)
	PN vs. NN	NP vs. NN	PP vs. NN	PN vs. NN	NP vs. NN	PP vs. NN	PN vs. NN	NP vs. NN	PP vs. NN	PN vs. NN	NP vs. NN	PP vs. NN	PN vs. NN	NP vs. NN	PP vs. NN
Tfrc	0.909	0.89	0.857	<0.0001	<0.0001	0.0012	>0.94	>0.47	>0.94	75	92.9	71.4	100	72.7	100
Mmp9	0.871	0.76	0.857	<0.0001	0.0102	0.0012	>0.455	>2.73	>2.73	91.7	57.1	71.4	72.7	100	100
S100a8	0.894	0.721	0.896	<0.0001	0.045	<0.0001	>0.829	>-0.095	>0.829	91.7	92.9	85.7	90.9	54.5	90
S100a9	0.693	0.669	0.727	0.11	0.1315	0.1365	>-0.07	>0.511	>0.856	91.7	57.1	57.1	54.5	81.8	100
Serpine1	0.875	0.864	0.883	<0.0001	<0.0001	<0.0001	>0.463	>1.022	>0.372	91.7	78.6	100	72.7	100	72.7
Hp	0.864	0.942	0.883	<0.0001	<0.0001	0.0001	>1.806	>1.806	>1.806	75	92.9	85.7	90.9	90.9	90.9
Timp1	0.985	0.929	0.701	<0.0001	<0.0001	0.1815	>0.682	>0.682	>1.022	100	78.6	42.9	90.9	90.9	100
Defb1	0.955	0.786	0.558	<0.0001	0.0024	0.7681	>0.951	>0.325	>0.325	83.3	64.3	57.1	100	90.9	90.9
Defb10	0.905	0.773	0.831	<0.0001	0.0052	0.0118	>1.154	>1.815	>1.154	83.3	57.1	85.7	90.9	100	90.9