Table 6.
Association between drug use and adverse events in retrospective study in China (N=751).
| Adverse events | Drug | Use, n (%) | Unadjusted HR | P-value | Adjusted HR | P-value | |
|---|---|---|---|---|---|---|---|
| Yes | No | (95%CI) | (95%CI) | ||||
| Arthralgia | Z | 488 (56.8) | 21 (34.4) | 2.03 (1.31, 3.14) | 0.002 | 2.10 (1.36, 3.26) | 0.001 |
| Arthralgia | Pto | 462 (56.4) | 47 (46.5) | 1.34 (1.00, 1.81) | 0.054 | 1.38 (1.02, 1.87) | 0.038 |
| Gastrointestinal disorders | Z | 468 (54.4) | 25 (41.0) | 1.58 (1.05, 2.36) | 0.027 | 1.58 (1.06, 2.37) | 0.025 |
| Gastrointestinal disorders | Lfx | 467 (54.8) | 26 (38.2) | 1.52 (1.02, 2.25) | 0.039 | 1.53 (1.02, 2.29) | 0.042 |
| Gastrointestinal disorders | Pto | 462 (56.4) | 31 (30.7) | 2.32 (1.61, 3.34) | <.001 | 2.32 (1.61, 3.34) | <.001 |
| Gastrointestinal disorders | PAS | 454 (60.0) | 39 (23.9) | 3.39 (2.43, 4.72) | <.001 | 3.34 (2.39, 4.65) | <.001 |
| Hematologic disorders | Z | 129 (15.0) | 2 (3.3) | 5.19 (1.28, 20.98) | 0.021 | 5.37 (1.33, 21.73) | 0.018 |
| Hematologic disorders | Pto | 124 (15.1) | 7 (6.9) | 2.35 (1.10, 5.04) | 0.028 | 2.38 (1.11, 5.10) | 0.029 |
| Hypokalemia | Cm | 20 (10.4) | 32 (4.4) | 2.91 (1.83, 4.65) | <.001 | 2.89 (1.81, 4.61) | 0.001 |
| Central Nervous system disorders | Pto | 92 (10.7) | 5 (5.0) | 2.44 (0.99, 6.99) | 0.052 | 2.48 (1.01, 6.10) | 0.048 |