Table 1. Summary of maternal observations and maternal and fetal pathology and vRNA burden.
| ID | Trimester of infection | duration of viremia (days) | Peak plasma viremia | Amn. Fluid* | Saliva | Difference in BPD+FL vs. HC (days) | Score of maternal path | Score of maternal RNA* | Score of MFI path | MFI RNA* | Fetal path | Fetal RNA* | Fetal ocular path |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 598248 | 3 | 11 | 17,400 | 0 | - | 16.5 | 0 | 6 | 7 | 1 | 11 | 6 | 0 |
| 357676 | 3 | 28 | 329,000 | 4 | + | 18.5 | 2 | 2 | 12 | 7 | 2 | 0 | 0 |
| 827577 | 1 | 71 | 668,000 | 0 | + | 19 | 2 | 4 | 8 | 0 | 4 | 15 | 2 |
| 660875 | 1 | 39 | 402,000 | 0 | - | 4.5 | 3 | 0 | 5 | 1 | 14 | 1 | 7 |
Summary of all maternal and fetal outcomes for each individual pregnancy, including quantitative vRNA burden and semiquantitative histopathology scores.
Scores are summed scoring for either vRNA levels or histopathology:
*RNA copies/mg tissue scoring: 0 = 0; 1–100 = 1; 100–1000 = 2, 1000–10000 = 3, 10000–50000 = 4.
Histopathology scoring: 0 = normal; 1 = minimal; 2 = mild; 3 = moderate; 4 = severe.
MFI = maternal-fetal interface (aggregate of decidua, placenta, amniotic and chorionic membranes)