S2.
Genotype and allele of ApaI, VDR-polymorphism, and BsmI-ApaI, ApaI-TaqI, BsmI-ApaI-TaqI combined genotypes of 74 melanoma patients and comparisons between groups of 100% VDR-positive cells (n=12) vs. <100% ( n=62); over the median (>20%) VDR-positive cells (n=36) vs. below or equal the median (≤20%) (n=38); and absence of VDR-positive cell (n=15) vs. remaining cases with detected VDR expression (n=59)
| VDR genotype or combined genotype | All melanoma patients (n=74) | 100% VDR-positive cells (n=12) | <100% VDR-positive cells (n=62) | OR (CI) 100% vs. <100% VDR-positive | P=100% vs. <100% VDR-positive | >20%a VDR-positive cells (n=36) | ≤20% VDR-positive cells (n=38) | OR (CI)>20%vs. ≤20% VDR-positive | P>20%vs.≤20% VDR-positive | VDR absence (0% positive)(n=15) | VDR presence (>0% positive)(n=59) | OR (CI) VDR absencevs. presence | PVDR absence vs. presence |
| ApaI genotype | |||||||||||||
| AA | 30 (40.5) | 8 (66.7) | 22 (35.5) | 3.64 (0.98–13.5) | 0.058 | 13 (36.1) | 17 (44.7) | 0.70 (0.27–1.78) | 0.450 | 8 (53.3) | 22 (37.3) | 1.92 (0.61–6.03) | 0.258 |
| Aa | 36 (48.6) | 4 (33.3) | 32 (51.6) | 0.47 (0.13–1.72) | 0.246 | 22 (61.1) | 14 (36.8) | 2.69 (1.05–6.90) | 0.037 | 5 (33.3) | 31 (52.5) | 0.45 (0.14–1.48) | 0.184 |
| aa | 8 (10.8) | 0 (–) | 8 (12.9) | –b | 0.339 | 1 (2.8) | 7 (18.4) | 0.13 (0.01–1.09) | 0.056 | 2 (13.3) | 6 (10.2) | 1.36 (0.24–7.52) | 0.660 |
| A allele | 96/148 (64.9) | 20/24 (83.3) | 76/124 (61.3) | 3.16 (1.02–9.80) | 0.038 | 48/72 (66.7) | 48/76 (63.2) | 1.17 (0.59–2.29) | 0.655 | 21/30 (70.0) | 75/118 (63.6) | 1.34 (0.56–3.18) | 0.509 |
| a allele | 52/148 (35.1) | 4/24 (16.7) | 48/124 (38.7) | 0.32 (0.10–0.98) | 0.038 | 24/72 (33.3) | 28/76 (36.8) | 0.86 (0.44–1.69) | 0.655 | 9/30 (30.0) | 43/118 (36.4) | 0.75 (0.31–1.78) | 0.509 |
| BsmI-ApaI combined genotype | |||||||||||||
| BBAA | 23 (31.1) | 5 (41.7) | 18 (29.0) | 1.75 (0.49–6.23) | 0.498 | 9 (25.0) | 14 (36.8) | 0.57 (0.21–1.56) | 0.271 | 6 (40.0) | 17 (28.8) | 1.65 (0.51–5.34) | 0.533 |
| BbAA | 5 (6.8) | 3 (25.0) | 2 (3.2) | 10.0 (1.46–68.3) | 0.028 | 4 (11.1) | 1 (2.6) | 4.62 (0.49–43.5) | 0.194 | 1 (6.7) | 4 (6.8) | 0.98 (0.10–9.49) | 1.000 |
| BbAa | 31 (41.9) | 1 (8.3) | 30 (48.4) | 0.10 (0.01–0.80) | 0.010 | 18 (50.0) | 13 (34.2) | 1.92 (0.75–4.90) | 0.169 | 5 (33.3) | 26 (44.1) | 0.63 (0.19–2.09) | 0.452 |
| Bbaa | 2 (2.7) | 0 (–) | 2 (3.2) | –b | 1.000 | 0 (–) | 2 (5.3) | –b | 0.494 | 0 (–) | 2 (3.4) | –b | 1.000 |
| bbAA | 2 (2.7) | 0 (–) | 2 (3.2) | –b | 1.000 | 0 (–) | 2 (5.3) | –b | 0.494 | 1 (6.7) | 1 (1.7) | 4.14 (0.24–70.4) | 0.367 |
| bbAa | 5 (6.8) | 3 (25.0) | 2 (3.2) | 10.0 (1.46–68.3) | 0.028 | 4 (11.1) | 1 (2.6) | 4.62 (0.49–43.5) | 0.194 | 0 (–) | 5 (8.5) | –b | 0.576 |
| bbaa | 6 (8.1) | 0 (–) | 6 (9.7) | –b | 0.581 | 1 (2.8) | 5 (13.2) | 0.19 (0.02–1.70) | 0.200 | 2 (13.3) | 4 (6.8) | 2.11 (0.35–12.8) | 0.595 |
| ApaI-TaqI combined genotype | |||||||||||||
| AATT | 4 (5.4) | 0 (–) | 4 (6.5) | –b | 1.000 | 0 (–) | 4 (10.5) | –b | 0.115 | 3 (20.0) | 1 (1.7) | 14.5 (1.39–152) | 0.025 |
| AATt | 14 (18.9) | 6 (50.0) | 8 (12.9) | 6.75 (1.74–26.1) | 0.008 | 9 (25.0) | 5 (13.2) | 2.20 (0.66–7.35) | 0.194 | 4 (26.7) | 10 (16.9) | 1.78 (0.47–6.74) | 0.463 |
| AAtt | 12 (16.2) | 2 (16.7) | 10 (16.1) | 1.04 (0.20–5.48) | 1.000 | 4 (11.1) | 8 (21.1) | 0.47 (0.13–1.72) | 0.246 | 1 (6.7) | 11 (18.6) | 0.31 (0.04–2.63) | 0.439 |
| AaTT | 12 (16.2) | 3 (25.0) | 9 (14.5) | 1.96 (0.44–8.67) | 0.399 | 9 (25.0) | 3 (7.9) | 3.89 (0.96–15.8) | 0.046 | 1 (6.7) | 11 (18.6) | 0.31 (0.04–2.63) | 0.439 |
| AaTt | 24 (32.4) | 1 (8.3) | 23 (37.1) | 0.15 (0.02–1.27) | 0.089^ | 13 (36.1) | 11 (28.9) | 1.39 (0.52–3.68) | 0.511 | 4 (26.7) | 20 (33.9) | 0.71 (0.20–2.51) | 0.761 |
| aaTT | 8 (10.8) | 0 (–) | 8 (12.9) | –b | 0.339 | 1 (2.8) | 7 (18.4) | 0.13 (0.01–1.09) | 0.056 | 2 (13.3) | 6 (10.2) | 1.36 (0.24–7.52) | 0.660 |
| BsmI-ApaI-TaqI combined genotype | |||||||||||||
| BBAATT | 1 (1.4) | 0 (–) | 1 (1.6) | –b | 1.000 | 0 (–) | 1 (2.6) | –b | 1.000 | 1 (6.7) | 0 (–) | –b | 0.203 |
| BBAATt | 10 (13.5) | 3 (25.0) | 7 (11.3) | 2.62 (0.57–12.0) | 0.351 | 5 (13.9) | 5 (13.2) | 1.06 (0.28–4.04) | 1.000 | 4 (26.7) | 6 (10.2) | 3.21 (0.77–13.3) | 0.110 |
| Continued | |||||||||||||