Fig. 5. Effects of ADL5859, LY2444296 or their combined administration vs water on locomotor activity in mice.

Mice were habituated in the locomotor chambers for 2 h first and then injected with water or drug(s). Total, ambulatory and stereotypic activities were continuously monitored after injections for 90 min using automated locomotor chambers. Data are expressed as mean ± S.E.M. beam breaks per 30-min period (60-90 min post injections) in (A) or per 5-min period (60-65 min post injections) in (B) and analyzed by one-way ANOVA. n = 8-10/group. The animal numbers for each treatment are as follows: H₂O (n=10), ADL5859 10 mg/kg (n=10), LY2444296 30 mg/kg (n=8) and the combined dose 3.84 mg/kg (n=8).