Table 1.
Chromosome breakage data in mentally retarded patients with or without fragile X syndrome and control individuals
| Group | Cells grown in medium 199
|
Cells grown in RPMI medium with FUdR (10−7
M)
|
||||
|---|---|---|---|---|---|---|
| Total no. of cells analyzed | Percentage of cells with non-Xq27 chromosome lesions average ± SD (range) | Percentage of cells with Xq27 chromosome lesions average ± SD (range) | Total no. of cells analyzed | Percentage of cells with non-Xq27 chromosome lesions average ± SD (range) | Percentage of cells with Xq27 chromosome lesions average ± SD (range) | |
| Mentally retarded fragile X syndrome patients (n = 24) | 1993 | 6.9 ± 11.0 (0–44) | 15.3 ± 12.9 (1–46) | 402a | 13.4 ± 10.3b (0–36) | 27.1 ± 19.0a (2–60) |
| Mentally retarded non-fragile X syndrome patients (n = 44) | 2329 | 5.4 ± 4.3 (0–20) | 1090c | 22.3 ± 10.7c (3–44) | ||
| Control individuals (n = 37) | 3368 | 6.8 ± 5.6 (0–21) | 403b | 10.0 ± 3.5b (4–14) | ||
a
Based on n = 8 subjects
b
Based on n = 6 subjects
c
Based on n = 40 subjects