Table 2.
Dietary Intake of Isoflavone and All-Cause Mortality in Women with Breast Cancer: the Breast Cancer Family Registry
| Number of Deaths | Person Years | HR (95% CI)1 | HR (95% CI)2 | |
|---|---|---|---|---|
| All women (n=6,235) | ||||
| Total Isoflavone, mg/d | ||||
| Q1 (< 0.342) | 359 | 13,938 | 1.0 (ref.) | 1.0 (ref.) |
| Q2 (0.343 – 0.674) | 343 | 14,072 | 0.96 (0.83, 1.12) | 1.01 (0.85, 1.19) |
| Q3 (0.675 – 1.493) | 291 | 14,227 | 0.81 (0.68, 0.95) | 0.89 (0.74, 1.07) |
| Q4 (≥1.494) | 231 | 13,560 | 0.67 (0.56, 0.80) | 0.79 (0.64, 0.97) |
| Ptrend <0.0001 | Ptrend = 0.01 | |||
| Women who reported pre-diagnosis diet (n=4,769)3 | ||||
| Total Isoflavone, mg/d | ||||
| Q1 (< 0.342) | 270 | 10,178 | 1.0 (ref.) | 1.0 (ref.) |
| Q2 (0.343 – 0.674) | 265 | 11,440 | 0.90 (0.76, 1.07) | 0.96 (0.80, 1.15) |
| Q3 (0.675 – 1.493) | 235 | 11,124 | 0.80 (0.67, 0.97) | 0.90 (0.74, 1.10) |
| Q4 (≥1.494) | 193 | 10,531 | 0.68 (0.55, 0.83) | 0.84 (0.66, 1.06) |
| Ptrend <0.0001 | Ptrend = 0.13 | |||
| Women who reported post-diagnosis diet (n=1,466)3 | ||||
| Total Isoflavone, mg/d | ||||
| Q1 (< 0.342) | 89 | 3,761 | 1.0 (ref.) | 1.0 (ref.) |
| Q2 (0.343 – 0.674) | 78 | 2,632 | 1.28 (0.92, 1.77) | 1.26 (0.90, 1.77) |
| Q3 (0.675 – 1.493) | 56 | 3,102 | 0.84 (0.59, 1.20) | 0.80 (0.55, 1.16) |
| Q4 (≥1.494) | 38 | 3,029 | 0.62 (0.41, 0.93) | 0.65 (0.41, 1.00) |
| Ptrend =0.008 | Ptrend = 0.02 | |||
Adjusted for age (continuous), study site, and total caloric intake (quartiles).
Additionally adjusted for race/ethnicity (non-Hispanic White, Black, Hispanic, and Asian/Pacific Islander/other), education (high school or less, some college or bachelor’s degree, or graduate degree), total fiber intake (quartiles), Health Eating Index (HEI)-2010 (quartiles), treatment type (surgery, radiation, chemotherapy, and hormone therapy), recreational physical activity (active, inactive), BMI (<25, 25–29.9, ≥30 kg/m2), alcohol use (never, <7 drinks/wk, ≥7 drinks/wk), smoking status (never, ever), and pack-years (continuous).
Three women did not report age at diagnosis and were excluded in the stratified analyses by pre- vs. post-diagnosis diet.