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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Am J Transplant. 2017 Apr 11;17(6):1656–1662. doi: 10.1111/ajt.14265

Figure 2. NK1.1+ cells are required for induction but not maintenance of islet transplant tolerance.

Figure 2

(A) Depletion of NK1.1+ cells prior to islet transplantation and dual Antibody treatment abrogates tolerance (p=0.0003,***). NK1.1 cell depletion on day 30 does not break tolerance (B) NK1.1+ cell depletion prevents transfer of islet transplant tolerance by adoptive transfer of Tim1+ Bregs from long-term tolerant islet recipients (p<0.0001.****).