Skip to main content
. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Am J Transplant. 2017 Apr 11;17(6):1656–1662. doi: 10.1111/ajt.14265

Figure 5. NK cells are required for islet transplant tolerance.

Figure 5

(A) Depletion of Nk1.1+ cells in NK-T cell deficient CD1d−/− mice further reduces the amount of long term tolerant mice (dual Ab vs. dual Ab+aNK p=0.0428,*; control vs. dual Ab+aNK, p=0.0079,**) (B) Beige mice (Lystbg/J) are resistant to tolerance induction by dual antibody treatment. Transfer of functional NK cells, isolated from B6 Splenocytes, restores the tolerizing effect of dual antibody treatment (p=0.0342,*)