Figure 6. Allograft function and proteinuria when De Novo DSA detected and at follow-up.
At the time of dnDSA detection, the mean iothalamate clearance was 55.0± 20.4 ml/min/BSA and at one year post detection, it decreased to 52.5 ±18.6 ml/min/BSA, p<0.01 (paired t-test) During the entire follow-up following dnDSA detection (mean 3.2±2.0 years); the mean iothalamate GFR decreased to 44.5 ± 21.7 ml/min/BSA, p=0.01. During the same follow-up, the mean 24 hr. urine proteinuria increased from 391.4±865.5 to 603.6 ± 1035.8, but this did not reach statistical significance p=0.24.