Figure 2.

Amino acid locations of Na_v1.7 disease-related mutations on the Na_v1.7 structure model. (A) The topology of human Na_v1.7 sodium channel. Cylinders represent the transmembrane segments, which are colored in gray except that the S4 voltage-sensing segments are colored in yellow. The lines represent the soluble regions between the transmembrane segments or the N/C-terminus. The two P helices between S5 and S6 segments are shown in cylinders. Mutations of Na_v1.7 are discriminately mapped on the topology scheme of Na_v1.7 by different colors, namely, IEM (blue), PEPD (red), CIP (cyan), DS (purple), SFN (green), and FEB (pink). (B) Intra-membrane view and intracellular views of the Na_v1.7 structure model. Mapping of disease-related mutations onto the Na_v1.7 structure model is highlighted by different colors. Summary of Na_v1.7 mutations is shown in different gray boxes