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. 2017 May 25;7:2397. doi: 10.1038/s41598-017-02581-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TgC6hp55 mice express the human TNFR1 under the CollagenVI promoter and show increased body size. (A) The construct used for the generation of the TgC6hp55 mice. (B) Macroscopic comparison of male and female transgenic mice versus their wild type littermates at the age of 3 months. (C) Comparison of the body weights of the two founders and the transgenic mice coming from them. At all time points there is no statistically significant difference between the two curves. (D) Q-PCR analysis for the detection of the human TNFR1 mRNA in different tissues from n = 3 TgC6hp55 mice. WAT, abdominal white adipose tissue; BAT, brown adipose tissue.