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. 2017 May 25;7:2397. doi: 10.1038/s41598-017-02581-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The TgC6hp55 phenotype is primary and independent of TNF, TNFR1 and insertion effects. (A) Body weight curve of Tnf ^+/+ (n = 12), Tnf ^−/−(n = 24), TgC6hp55Tnf ^+/+ (n = 12) and TgC6hp55Tnf ^−/− (n = 21) mice. (B) Body length comparison of Tnf ^+/+ (n = 6), Tnf ^−/−(n = 11), TgC6hp55Tnf ^+/+ (n = 6) and TgC6hp55Tnf ^−/− (n = 9) mice. (C) Body weight curve of Tradd ^+/+ (n = 15), Tradd ^D/D (n = 11), TgC6hp55Tradd ^+/+ (n = 19) and TgC6hp55Tradd ^D/D (n = 8) mice. (D) Body length comparison of Tradd ^+/+ (n = 8), Tradd ^D/D (n = 7), TgC6hp55Tradd ^+/+ (n = 7) and TgC6hp55Tradd ^D/D (n = 7) mice. Data represent mean ± SEM.