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. 2017 May 25;7:2426. doi: 10.1038/s41598-017-02587-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of SLAB51 on proteasomal activity. Proteasome activity in SLAB51 treated and untreated wt (left) and AD (right) mice. The ChT-L, T-L, PGPH and BrAAP activities of the 20S proteasome and the ChT-L activity of the 26S proteasome were measured in brain homogenates as described in the Methods section. Results are expressed as fluorescence units (U. F.). Data points marked with an asterisk are statistically significant compared to untreated 8-week-old mice (*p < 0.05). Data points marked with a hash are statistically significant compared to their respective control mice in the same time point (*p < 0.05).