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. 2017 May 25;7:2426. doi: 10.1038/s41598-017-02587-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of SLAB51 on proteasomal substrates. Detection of the levels of ubiquitinated proteins (panel A), p27 (panel B) and p53 (panel C) in SLAB51 treated and untreated wt and AD mice. The densitometric analyses obtained from five separate blots and representative immunoblots are shown. Equal protein loading was verified by using an anti-GAPDH antibody. The detection was executed by an ECL western blotting analysis system. Data points marked with an asterisk are statistically significant compared to 8-week-old control mice (*p < 0.05). Data points marked with a hash are statistically significant compared to their respective control mice at the same time point (^#p < 0.05). Uncropped gels are reported in Supplemental Figure 1.