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. 2017 May 26;5:59. doi: 10.3389/fcell.2017.00059

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Copyright © 2017 Gentzel and Schambony.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dishevelled in Wnt/Frizzled signaling. (A) DVL relays Wnt/Frizzled signals to multiple signaling pathways to regulate cellular functions including mitosis, transcription, polarity, and migration. (B) Heatmap representation of the conservation of all three DVL proteins in human, rat, mouse, and frog. Sequence alignments were calculated using Clustal Omega with the following input sequences: Homo sapiens DVL1: O14640, DVL2: O14641, DVL3: Q92997, Rattus norvegicus DVL1: Q9WVB9, DVL2: D3ZB71, DVL3: D4ADV8, Mus musculus DVL1: P51141, DVL2: Q60838, DVL3: Q61062, Xenopus laevis DVL2: P51142, DVL3: Q6DKE2 (Uniprot Accession numbers), Xenopus laevis DVL1: NCBI XP_018081523. Red indicates 100% identity and Green indicates no identity of amino acids at the respective position. Conservation scores were calculated according to Livingstone and Barton (1993). Functional domains or motifs are indicated by correspondingly labeled boxes; for details and references see text.