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. 2017 May 26;10:149. doi: 10.3389/fnmol.2017.00149

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Copyright © 2017 Neuhaus, Krämer, Neuhoff, Gölz, Thal and Förster.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Influence of WY-14643 on brain water content [%] 24 h after controlled cortical impact in a mouse traumatic brain injury model. 60 mg/kg body weight of WY-14643 reduced the increase of brain water content in the ipsilateral brain hemisphere of wild type C57Bl/6 mice significantly. Addition of PPARα antagonist GW6471 did not reverse the beneficial effects of WY-14643 (A). Administration of 60 mg/kg body weight WY-14643 did not decrease brain water content of PAI-1 knockout mice (PAI-1^-/-) after TBI. (B). Statistical significance was labeled with ^∗ (p < 0.05). Data are presented as means ± SEM (wild type: n = 6–12; PAI-1^-/-: n = 6–7).