Table 3.
Cox proportional hazards regression models
| Model 1 | Model 2 | Interaction Term | |||
|---|---|---|---|---|---|
| HR | 95% CI | HR | 95% CI | ||
| Antipsychotics (2 year mortality) | sex*antipsychotics | ||||
| All participants | 1.16 | 0.94–1.43 | 0.91 | 0.73–1.14 | p = 0.962 |
| Male participants | 1.24 | 0.82–1.87 | 0.79 | 0.51–1.24 | |
| Female participants | 1.15 | 0.90–1.46 | 0.90 | 0.70–1.15 | |
| Antidepressants (2 year mortality) | sex*antidepressants | ||||
| All participants | 1.01 | 0.84–1.21 | 0.96 | 0.78–1.17 | p = 0.047 |
| Male participants | 0.96 | 0.67–1.37 | 0.61* | 0.40–0.92 | |
| Female participants | 1.03 | 0.84–1.28 | 1.09 | 0.87–1.38 | |
| Benzodiazepines (first-year mortality) | sex*benzodiazepines | ||||
| All participants | 1.38* | 1.08–1.77 | 1.13 | 0.86–1.47 | p = 0.029 |
| Male participants | 2.07* | 1.29–3.32 | 1.37 | 0.77–2.45 | |
| Female participants | 1.21 | 0.91–1.62 | 0.96 | 0.71–1.31 | |
| Benzodiazepines (second-year mortality) | sex*benzodiazepines | ||||
| All participants | 0.95 | 0.73–1.24 | 0.72* | 0.54–0.96 | p = 0.964 |
| Male participants | 0.90 | 0.51–1.59 | 0.81 | 0.45–1.45 | |
| Female participants | 0.98 | 0.72–1.33 | 0.73 | 0.53–1.02 |
Notes: Analyses of antipsychotics and benzodiazepines include related drugs, as described in methods. Hazard ratios marked with * are statistically significant (p < 0.05). HR Hazard ratio. CI Confidence interval. Model 1 shows the unadjusted, univariate associations between drug use and mortality. Model 2 includes all available confounders, selected through the process described in the statistics section. Interaction Term shows the p-values for the respective interaction terms applied to Model 2