Fig. 3.

Gene expression profiling associated with response to abatacept/methotrexate in subset 1. Baseline samples from subset 1 (n = 36 (17 responders (R) and 19 non-responders (NR)) were hybridized on 4 × 44 K whole human genome microarrays. a The t test with the Benjamini–Hochberg correction for estimation of the false discovery rate (p < 0.05) was used to identify 87 transcripts (red dots) with dysregulation that was associated with response (R vs NR). b Hierarchical clustering: Pearson coefficient and complete linkage metrics were used to obtain the transcripts and sample dendrograms. Fold change (FC) is the ratio of relative abundance of transcripts in patients with rheumatoid arthritis vs control pool