Fig. 5.

Pre-silencing of mitochondrial respiratory chain associated with abatacept/methotrexate (ABA/MTX) response. a Electron transport chain (ETC) WP111-41171 WikiPathway (http://www.wikipathways.org/index.php/Pathway:WP111). In the 87 mRNA dysregulated between responders (R) and non-responders (NR) to ABA/MTX, there was highly significant enrichment of mRNA involved in ETC (p value = 1.6.10^-9). The p value was determined by standard hypergeometric distribution. This enrichment involved 7 mRNA from the 87 transcripts, which are highlighted in yellow among the 104 proteins from the whole ETC pathway. b Gene expression level expressed as fold change (FC) (patients with RA/control pool) for these 7 mRNA in 17 R and 19 NR. c Principal component analysis of 17 R and 19 NR performed with gene expression level (fold change) of the 104 mRNA from the whole ETC pathway. Component 1: 40.3%; component 2: 16.7%