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. 2017 May 25;17:6. doi: 10.1186/s12899-017-0032-9

Fig. 2.

Fig. 2

Bladder histology after disulfide HMGB1 and pretreatment with intravesical or intraperitoneal HMGB1 receptor antagonists. (a) Intravesical vehicle control instillation (n = 5), (b) intravesical TAK242 (n = 4), (c) intraperitoneal TLR4 antagonist TAK242 (n = 5), (d) 10 μg disulfide HMGB1 induced submucosal fibrosis with lamina propria expansion (black arrows) (n = 6), (e) intravesical FPS-ZM1 pretreatment (n = 6) or (f) intraperitoneal RAGE antagonist FPS-ZM1 (n = 3)