Table 1.
Clinic-pathological characteristics and univariate analysis of factors associated with OS and RFS
| OS | RFS | ||||||
|---|---|---|---|---|---|---|---|
| Variable | n | HR | 95% CI | P value | HR | 95% CI | P value |
| Sex (female vs male) | 5 vs 34 | 1.179 | 0.345–4.031 | 0.792 | 1.016 | 0.229–4.509 | 0.984 |
| Age years (≤52 vs >52) | 21 vs 18 | 0.754 | 0.312–1.824 | 0.531 | 1.680 | 0.596–4.732 | 0.326 |
| AFP (ng/ml; ≤20 vs >20) | 13 vs 25 | 1.734 | 0.629–4.778 | 0.287 | 1.214 | 0.414–3.555 | 0.724 |
| HBsAg (IU/mL; <1000 vs ≥1,000) | 6 vs 28 | 5.915 | 0.784–44.637 | 0.085 | 1.561 | 0.340–7.179 | 0.567 |
| HBeAg (negative vs positive) | 33 vs 6 | 8.931 | 2.661–29.982 | 0.000 | 3.361 | 0.848–13.321 | 0.085 |
| HBV-DNA (IU/mL; <1000 vs ≥1,000) | 10 vs 9 | 7.798 | 1.580–38.496 | 0.012 | 2.808 | 0.647–12.186 | 0.168 |
| HCV-Ab (S/CO; <10.9 vs ≥10.9) | 8 vs 12 | 0.579 | 0.152–2.207 | 0.424 | 0.808 | 0.189–3.455 | 0.774 |
| Liver cirrhosis (no vs yes) | 13 vs 26 | 1.245 | 0.478–3.243 | 0.654 | 2.118 | 0.596–7.519 | 0.246 |
| Tumor size (cm; ≤5 vs >5) | 25 vs 14 | 4.336 | 1.753–10.722 | 0.001 | 2.302 | 0.793–6.686 | 0.125 |
| Tumor number (single vs multiple) | 31 vs 8 | 3.155 | 1.145–8.695 | 0.026 | 1.679 | 0.455–6.190 | 0.437 |
| Vascular invasion (no vs yes) | 26 vs 13 | 3.352 | 1.358–8.272 | 0.009 | 3.806 | 13.60–10.646 | 0.011 |
| Capsule (no vs yes) | 12 vs 26 | 1.319 | 0.474–3.670 | 0.596 | 0.775 | 0.259–2.317 | 0.648 |
| Tumor differentiation (I-II vs III-IV) | 21 vs 16 | 0.798 | 0.308–2.068 | 0.642 | 0.664 | 0.221–1.992 | 0.465 |
Note: Univariate analysis, Cox proportional hazards regression model
Abbreviations: HR, Hazard ratio; 95% CI, 95% confidence interval; AFP, alpha-fetoprotein; HCV-Ab, HCV antibody