Table 7.
Systemic cytokines/chemokines measured in serum of piglets during course of infection using FMIA
| Negative | E. coli O104:H4 | E. coli O157:H7 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Median (min–max) | Median (min–max) | Median (min–max) | |||||||
| Time range: | T1, n = 3 | T2; n = 3 | T3; n = 2 | T1; n = 5 | T2; n = 6 | T3; n = 5 | T1; n = 3 | T2; n = 4 | T3; n = 1 |
| IL1β pg/ml | 6.3 (6.3–14.6) | 4.7 (3.3–6.5) | 5.6 (5.6–5.7) | 5.6 (5.0–8.1) | 5.6 (4.6–8.4) | 5.9 (3.9–7.0) | 7.7 (6.7–8.4) | 7.5 (5.5–8.9) | 8.8 |
| IL12 pg/ml | 279.7 (195.0–413.9) | 104.0 (101.4–126.9) | 2263.4 (106.5–4420.4) | 194.9 (152.8–10856.4) | 165.9 (91.3–714.8) | 91.3 (42.4–139.8) | 134.7 (126.9–243.1) | 197.1 (93.9–6247.2) | 352.5 |
| CCL2 pg/ml | 807.1 (730.7–3973.4) | 1529.7 (840.6–2935.0) | 2550.6 (1751.2–3350.0) | 536.4 (251.5–1176.4) | 1372.8 (570.1–3598.0) | 1917.8 (826.3–4011.7) | 603.1 (441.9–672.1) | 453.9 (365.4–513.5) | 677.3 |
| IFNγ pg/ml | 2.8 (0.0–13.6) | 0.0 (0.0–16.3) | 4.0 (0.0–8.0) | 0.0 (0.0–4.2) | 38.7 (2.8–582.8) | 5.5 (0.0–63.6) | 0.0 (0.0–4.2) | 48.3 (46.2–98.3) | 30.5 |
| IL10 pg/ml | 49.4 (45.0–51.5) | 11.2 (9.2–15.4) | 17.1 (16.7–17.5) | 29.5 (22.0–33.1) | 20.1 (18.8–30.0) | 11.5 (9.8–17.5) | 22.7 (22.5–26.2) | 19.4 (14.6–31.4) | 26.7 |
T1 timerange 1, preinfectionem, T2 timerange 2, day 4–day 6 p.i., T3 timerange, day 7–day 12 p.i.