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Model for redox-regulated platelet CD36 prothrombotic signaling. Recognition of oxLDL by platelet CD36 induces a signaling pathway that involves the activation of Src family kinases, NOX, and accumulation of O2•− and H2O2. Generation of these ROS lead to the activation of redox sensitive MAPK ERK5 through a mechanism that is not yet clear. ERK5 activation promotes platelet integrin activation, aggregation, and thrombus formation in conditions of hyperlipidemia and oxidant stress.
