Table 1.

Associations between TP53 rs1800371 and breast cancer risk in African-American women in the AMBER, ROOT, and AABC Consortia

TP53 rs1800371	Controls	All cases	p-value	ER+cases	p-value	ER-cases	p-value
All women
AMBER
N	3698	3130	—	1674	—	963	—
MAF	0.014	0.016	—	0.015	—	0.016	—
OR (95% CI)*	—	1.17 (0.84–1.62)	0.34	1.08 (0.73–1.60)	0.70	1.18 (0.73–1.92)	0.49
ROOT
N	2029	1657	—	403	—	374	—
MAF	0.011	0.012	—	0.017	—	0.013	—
OR (95% CI)**	—	1.10 (0.58–2.08)	0.78	2.31 (0.91–5.86)	0.077	1.04 (0.35–3.07)	0.95
AABC
N	1917	2120	—	1117	—	591	—
MAF	0.014	0.014	—	0.013	—	0.014	—
OR (95% CI)	—	1.08 (0.71–1.65)	0.70	1.25 (0.74–2.12)	0.41	1.00 (0.53–1.86)	0.99
Premenopausal women
AMBER
N	1490	1218	—	631	—	398	—
MAF	0.013	0.019	—	0.016	—	0.019	—
OR (95% CI)*	—	1.79 (1.07–2.99)	0.027	1.52 (0.80–2.87)	0.20	1.98 (0.95–4.11)	0.07
ROOT
N	898	724	—	146	—	169	—
MAF	0.010	0.012	—	0.015	—	0.013	—
OR (95% CI)**	—	1.39 (0.51–3.78)	0.52	1.84 (0.35–9.77)	0.48	1.17 (0.22–6.28)	0.86
Meta-analysis of AMBER and ROOT
Per A allele OR (95% CI)***	—	1.72 (1.08–2.76)	—	1.64 (0.88–3.05)	—	1.72 (0.87–3.40)	—
p-value for testing association	—	0.023	—	0.12	—	0.12	—
p-value for testing heterogeneity	—	0.89	—	0.96	—	0.95	—

*Logistic regression models adjusted for age, principal components of ancestry, geographic region, study, and DNA source

**Logistic regression models adjusted for study sites, age, and principal components of the genotypes for ancestry

***Fixed effect meta-analysis based on study-specific ORs and SEs from BWHS, WCHS, CBCS, and ROOT