Table 1.

Predictive relationships between cell cycle growth phases based on cell proliferation markers

Cell line class	S:MI	S:MER	MER:MI	Significant predictive relationships
HMEC	<0.0001**	0.006**	0.0120*	S→MER, MER→MI, and S→MI
BL	0.5996	0.5954	0.1659	N/A
LumB	0.0041*	0.4769	<0.0001**	MER→MI, S→MI
CL	0.4827	0.3758	0.0051*	MER→MI
Her2E	0.0706	0.3090	0.1309	N/A

Breast cancer cell lines exhibit impaired cell cycle regulation and S/G₂/M progression kinetics. Associations between the S:MI, S:MER, and MI:MER growth parameters were assessed for each class. Significant correlations are shown in the right column. Only the HMEC class showed significant associations among all three parameters; all breast cancer cell line classes exhibited aberrant progression kinetics for at least one cell cycle phase transition. *p-value < 0.05, **p-value that remains significant when controlling for false discovery rate (5%)