Table 1.
Incidence rate of LM2-4luc+/H2N metastasis in various organs of mice receiving a total of 6 doses of either T-siPLK1-NP or T-siSCR-NP, as quantified by ex vivo IVIS imaging as shown in Supplementary Fig. S5(C). The tumor signal in each organ is reported as fold-change over the signal from the same organ of normal mice (n=4 for normal mice, n=8 mice/treatment group). Dose and schedule as shown in Fig. 4(A).
| Group | Parameter | Brain | Lung | Liver | Spleen | Kidney | Lymph nodes |
Spine | Total tumor signal |
Ratio over saline |
|---|---|---|---|---|---|---|---|---|---|---|
| Saline | Incidence rate | 2/8 | 8/8 | 2/8 | 1/8 | 1/8 | 5/8 | 4/8 | ||
| Tumor signal | 288 | 405 | 73 | 16 | 12 | 240 | 1717 | 2749 | 1.00 | |
| T-siSCR-NP | Incidence rate | 1/8 | 7/8 | - | - | - | 4/8 | 4/8 | ||
| Tumor signal | 139 | 443 | - | - | - | 131 | 1322 | 2036 | 0.74 | |
| T-siPLK1-NP | Incidence rate | - | 4/8 | - | - | - | 1/8 | 3/8 | ||
| Tumor signal | - | 26 | - | - | - | 3 | 939 | 968 | 0.35 |