Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Feb 17;76(3):576–584. doi: 10.1136/annrheumdis-2016-209428

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

Conditional deletion of Bmal1 in Col2a1-expressing cells results in disruption of the circadian rhythms in mouse intervertebral discs (IVDs). (A) IHC of BMAL1 in 3-month-old wild type (WT) and KO mice (magnification: upper panels 10× and lower panels 40×); n=3. (B) Representative bioluminescence traces of WT (blue) and Bmal1 cKO (red) mouse IVD explant cultures; n=6. Arrow indicates treatment with dexamethasone. (C) Live bioluminescence imaging of IVDs from WT and Bmal1 cKO IVDs from mice on a PER2::Luc background.

HHS Vulnerability Disclosure