Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Nicotinamide (NAM) is methylated by nicotinamide N-methyltransferase (NNMT) using the universal methyl donor S-Adenosylmethionine (SAM). The methylated product N1-methylnicotinamide (MNAM) is further oxidized by aldehyde oxidase (Aox) into two related compounds 2py and 4py. All three metabolites are eventually excreted in the urine.
