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. 2017 Feb 28;13(5):991–994. doi: 10.1080/15548627.2017.1291480

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© 2017 The Author(s). Published with license by Taylor & Francis

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 1. — The primary role of the human peroxisomal AAA-complex is to prevent pexophagy. Both yeast (Pex1, Pex6 and Pex15) and human (PEX1, PEX6 and PEX26) AAA-complexes extract Ub-PEX5 from the peroxisomal membrane. However, while the main purpose of such extraction in yeast cells is Pex5 recycling for repeated rounds of PTS1-protein import, the extraction of Ub-PEX5 in human cells is essential to prevent pexophagy. Since the yeast AAA-complex also prevents pexophagy, but independent of Pex5, there must be another pexophagic signal (protein X) removed from the peroxisomal membrane by the AAA-complex in yeast.