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Atg5 or Rb1cc1 deficiency does not affect the lysosomal degradation pathway. (A) MA9 wild-type, MA9-atg5−/− and MA9-rb1cc1−/− leukemia cells were treated with chloroquine at 25 μM for 6 h followed by TEM imaging. Scale bar: 500 nm. (B) MA9 wild-type, MA9-atg5−/− and MA9-rb1cc1−/− leukemia cells cultured under basal condition were harvested and used for western blot analysis (n = 2 repeats).
