Figure 6.

Expression of αvβ6 in malignant human colon carcinoma. (A–E) Representative β6 immunostaining of normal human colon (A) or malignant colon carcinoma tissue (B–E). A negative (B) and a positive (C) tumor sample are shown. β6 Immunostaining is shown for a separate carcinoma sample in D, with tumor cells infiltrating the stroma showing high expression of the receptor. Heterogeneous receptor expression in another primary tumor, with intense upregulation and preferential localization to tumor islets, is illustrated in E. (F) The corresponding negative control for the tumor shown in E. Scale bars: 100 μm (A–C, E, and F) and 50 μm (D).