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. 2005 Jan 20;115(2):428–433. doi: 10.1172/JCI23269

Figure 2.

Figure 2

Reimaging of a neuritic plaque in a living PDAPP;Thy-1:YFP double-transgenic mouse. (A and B) A single neuritic plaque imaged through a cranial window in a living PDAPP;Thy-1:YFP double-transgenic mouse with 2-photon microscopy on the initial day of surgery. (C and D) The same plaque shown in A and B, imaged 3 days after surgery. Multiple neurites of normal caliber and dystrophic neurites (arrows) were easily visualized with YFP fluorescence (green). A and C show both methoxy-X04–labeled amyloid (blue) and YFP-labeled neurites. B and D are identical to A and C, respectively, but only show the YFP signal. In the absence of any treatment, the relative number and size of amyloid-associated dystrophic neurites did not significantly change over a 72-hour period. Each panel is a projection of multiple focal planes that span approximately 20 μm. Scale bar: 20 μm.