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. Author manuscript; available in PMC: 2017 May 26.
Published in final edited form as: Prog Neuropsychopharmacol Biol Psychiatry. 2017 Jan 5;75:45–53. doi: 10.1016/j.pnpbp.2017.01.001

Fig. 2.

Fig. 2

Forest plot of effect sizes of α7 nicotinic agonists on the novel object recognition task and water maze tasks in rodent models of cognitive impairment. Meta-analysis demonstrated a significant effect in the novel object recognition task (A) compared to vehicle (Effect size (ES) = −0.73, 95% CI = −1.00 to −0.45, p < 0.001), and a significant effect in the water maze task (B) compared to vehicle (ES = − 1.18, 95% CI = −1.69 to −0.66, p < 0.001). Note: negative effect size favors drug treatment.