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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Alcohol Clin Exp Res. 2016 Sep 20;40(11):2320–2328. doi: 10.1111/acer.13209

Figure 4. Phosphorylated PKR protein expression is correlated with age of onset of chronic ethanol (EtOH) exposure in rodents.

Figure 4

Control mice and EtOH-treated mice were assessed for p-PKR expression at various ages. Mice were exposed to EtOH beginning at 1, 4, or 9 months and were fed EtOH according to the Lieber-DeCarli diet for 28 days. p-PKR expression was measured thereafter and was negatively correlated with age of onset of EtOH exposure, with the youngest mice (1 mo. old) having the greatest p-PKR expression, which decreased with age at the time of EtOH exposure. Control mice also showed a negative correlation with respect to age and p-PKR expression. *p < 0.05 vs. control