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. Author manuscript; available in PMC: 2018 May 22.
Published in final edited form as: Curr Biol. 2017 May 4;27(10):1413–1424.e4. doi: 10.1016/j.cub.2017.03.077

Figure 4. Theta oscillations in the hippocampus and RN at P12 are coherent and mutually interactive during AS.

Figure 4

(A) Representative theta-filtered LFPs (4-7 Hz) in the hippocampus (purple trace) and RN (red trace) in a P12 rat across behavioral states.

(B) Left: Mean LFP-LFP coherence spectra between hippocampus and RN (19 pups, 19 LFP pairs) during AW (red), BQ (green), and AS (blue). Shaded gray area indicates theta-frequency range. Right: Mean (+ SE) theta coherence across behavioral states. Asterisk denotes significant difference from AW and BQ, p < 0.001. Hashtag indicates significant difference from AW, p < 0.05.

(C) Left: Mean Granger causality spectra for pups exhibiting significant bidirectional interactions between hippocampus and RN (p < 0.01; 9 pups, 9 LFP pairs). Right: Mean (+ SE) peak Granger causality value within theta-frequency range (9 pups, 9 LFP pairs). See also Figure S4.