Table 1. Pharmacokinetic variables (mean, standard deviation, n = 34) for florfenicol.
Variable | Units | Mean | SD |
---|---|---|---|
Cmax | mg/L | 3.04 | 1.82 |
AUC | h*mg/L | 53.7 | 9.32 |
AUMC | h*h*mg/L | 650 | 282 |
Tmax | h | 1.94 | 0.87 |
Cl/F | L/h/kg | 0.23 | 0.04 |
T1/2 | h | 11.0 | 9.02 |
Pharmacokinetic variables determined by non-compartmental analysis for florfenicol administered intramuscularly at a dose rate of 15mg/kg; data for two bioequivalent products (Nuflor and Norfenicol). Cmax = maximum concentration; AUC = area under plasma concentration-time curve; AUMC = area under the first moment curve; Tmax = time to reach maximum concentration; Cl/F = drug clearance scaled by bioavailability; T1/2 = terminal half-life. Values are geometric means except for Tmax (arithmetic mean) and T1/2 (harmonic mean).