Table 3. Integration of pharmacokinetic (in vivo plasma concentration) and pharmacodynamic (MPC determined in broth and serum) variables for florfenicol (mean and standard deviation).

Organism	Parameter	Units	Broth		Serum
			Mean	SD	Mean	SD
Pasteurella multocida	Cav0-48/MPC		0.20	0.04	0.27	0.06
	Cav0-24/MPC		0.28	0.10	0.39	0.13
	Cav24-48/MPC		0.13	0.05	0.17	0.07
	Cmax/MPC		0.55	0.50	0.76	0.69
	T>MPC	h	0		0
Actinobacillus pleuropneumoniae	Cav0-48/MPC		0.29	0.06	0.23	0.05
	Cav0-24/MPC		0.41	0.14	0.32	0.11
	Cav24-48/MPC		0.18	0.08	0.15	0.06
	Cmax/MPC		0.81	0.73	0.63	0.58
	T>MPC	h	0		0

C_av = average plasma concentration (μg/mL) for time periods 0–48, 0–24 and 24–48 h. C_max = maximum plasma concentration (μg/mL); T>MPC = Time for which plasma concentration exceeded MPC (h). Individual animal C_av and C_max obtained from 34 pigs divided by mean MPCs for six isolates of each species measured in broth and serum.