Table 4. PK/PD modelling for P. multocida from time-kill curves (means and standard deviation, n = 6).
| Parameter (units) | Broth | Serum | ||
|---|---|---|---|---|
| Mean | SD | Mean | SD | |
| Log E0 (CFU/mL) | 2.50 | 0.36 | 2.43 | 0.50 |
| Log Emax (CFU/mL) | -7.02 | 0.70 | -6.39 | 1.51 |
| Log Emax—Log E0 (CFU/mL) | -9.52 | 0.34 | -8.83 | 1.00 |
| Gamma | 3.10 | 0.50 | 3.63 | 1.23 |
| AUC24h/MIC for bacteriostatic action (h) | 25.7 | 2.11 | 24.2 | 2.27 |
| AUC24h/MIC50 (h) | 35.7 | 2.77 | 32.3 | 3.13 |
| AUC24h/MIC for bactericidal action (h) | 40.2 | 3.39 | 37.3 | 4.00 |
| AUC24h/MIC for 4 log10 reduction (h) | 47.0 | 4.90 | 43.9 | 5.69 |
E0 = difference in number of organisms (CFU/mL) in control sample in absence of drug between time 0 and 24 h; Emax = difference in number of organisms (CFU/mL) in presence of florfenicol between time 0 and 24 h; AUC24h/MIC50 = concentration producing reduction in count to 50% of the Emax; Gamma = slope of the curve; detection limit = 33 CFU/mL.