Table 5. PK/PD modelling for A. pleuropneumoniae from time-kill curves (mean, and standard deviation, n = 6).
| Parameter (units) | Broth | Serum | ||
|---|---|---|---|---|
| Mean | SD | Mean | SD | |
| Log E0 (CFU/mL) | 2.80 | 0.09 | 2.46 | 0.75 |
| Log Emax (CFU/mL) | -5.30 | 0.44 | -5.29 | 1.48 |
| Log Emax—Log E0 (CFU/mL) | -8.10 | 0.35 | -7.75 | 0.73 |
| Gamma | 3.06 | 1.11 | 3.62 | 1.66 |
| AUC24h/MIC for bacteriostatic action (h) | 24.6 | 1.83 | 30.1 | 13.7 |
| AUC24h/MIC50(h) | 31.1 | 1.38 | 42.1 | 14.5 |
| AUC24h/MIC for bactericidal action (h) | 43.8 | 5.59 | 58.4 | 19.2 |
| AUC24h/MIC for 4 log10 reduction (h) | 58.6 | 9.87 | 79.6 | 23.6 |
E0 = difference in number of organisms (CFU/mL) in control sample in absence of drug between time 0 and 24 h; Emax = difference in number of organisms (CFU/mL) in presence of florfenicol between time 0 and 24 h; AUC24h/MIC50 = concentration producing reduction in count to 50% of the Emax; Gamma = slope of the curve; detection limit = 33 CFU/mL.