Table 2. Incidence and adjusted hazard ratio of colorectal cancer stratified by sex, age and comorbidity compared among inflammatory bowel disease patients with cholecystectomy and without cholecystectomy.
| Cholecystectomy | ||||||||
|---|---|---|---|---|---|---|---|---|
| No | Yes | |||||||
| Variables | No. of Events | PY | Rate# | No. of Events | PY | Rate# | Crude HR (95%CI) | Adjusted HR (95%CI)† |
| All | 6 | 4245 | 1.41 | 7 | 4006 | 1.75 | 1.24(0.42, 3.68) | 0.76(0.25, 2.32) |
| Gender | ||||||||
| Female | 1 | 1933 | 0.52 | 3 | 2025 | 1.48 | 2.84(0.30, 27.3) | 1.62(0.16, 16.4) |
| Male | 5 | 2312 | 2.16 | 4 | 1981 | 2.02 | 0.94(0.25, 3.51) | 0.57(0.14, 2.22) |
| Age | ||||||||
| ≤ 49 | 2 | 2421 | 0.83 | 0 | 1319 | 0 | - | - |
| 50–64 | 1 | 833 | 1.2 | 3 | 1233 | 2.43 | 2.07(0.22, 19.9) | 1.74(0.18, 16.9) |
| ≧65 | 3 | 991 | 3.03 | 4 | 1454 | 2.75 | 0.92(0.21, 4.10) | 0.74(0.16, 3.37) |
| Comorbidity‡ | ||||||||
| No | 3 | 3430 | 0.87 | 4 | 2345 | 1.71 | 1.91(0.43, 8.54) | 1.43(0.32, 6.47) |
| Yes | 3 | 816 | 3.68 | 3 | 1661 | 1.81 | 0.49(0.10, 2.44) | 0.52(0.10, 2.56) |
Rate#, incidence rate, per 1000 person-years; Crude HR, relative hazard ratio
Adjusted HR†: multivariable analysis including age, sex, and comorbidities
Comorbidity‡: Patients with any one of the comorbidities hypertension, diabetes, hyperlipidemia, stroke, congestive heart failure, colorectal adenomas, and obesity were classified as the comorbidity group