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. 2017 May 26;12(5):e0177745. doi: 10.1371/journal.pone.0177745

Table 4. Incidence of colorectal cancer location using Cox model measured hazards ratio by type of cholecystectomy.

Variables(ICD-9 code) Event Rate# Crude HR* Adjusted HR (95% CI)
(95% CI)
Colon cancer
Non-cholecystectomycohort (N = 525) 6 1.41 1(Reference) 1(Reference)
Cholecystectomy
Lapraroscopic cholecystectomy (N = 282) 2 0.88 0.62(0.13, 3.07) 0.44(0.09, 2.22)
Non-lapraroscopic cholecystectomy (N = 243) 5 2.9 2.06(0.63, 6.76) 1.11(0.32, 3.78)
Colon cancer (except rectum) (ICD-9 153)
Non-cholecystectomycohort (N = 525) 3 0.71 1(Reference) 1(Reference)
Cholecystectomy
Lapraroscopic cholecystectomy (N = 282) 1 0.44 0.62(0.07, 5.99) 0.40(0.04, 3.92)
Non-lapraroscopic cholecystectomy (N = 243) 5 2.9 4.21(1.01, 17.6)* 2.81(0.63, 12.5)
Rectal cancer (ICD-9 154)
Non-cholecystectomycohort (N = 525) 3 0.71 1(Reference) 1(Reference)
Cholecystectomy
Lapraroscopic cholecystectomy (N = 282) 1 0.44 0.61(0.06, 5.87) 0.42(0.04, 4.80)
Non-lapraroscopic cholecystectomy (N = 243) 0 0 - -

Rate#, incidence rate, per 1,000 person-years; Crude HR *, relative hazard ratio; Adjusted HR†: multivariable analysis including age, sex, and comorbidities of hyperlipidemia, diabetes, liver cirrhosis, hypertension, COPD, stroke, CAD, and HCV